Azelaic acid is a saturated dicarboxylic acid found in wheat, rye, and barley.
It is also produced by Malassezia furfur, known as Pityrosporum ovale, it is a species of fungus. Azelaic acid is effective against mild to moderate acne.
It halts the growth of skin bacteria that cause acne, and keeps the skin pores clear.
Azelaic acid's is antimicrobial in action and it inhibits the formation of microbial cellular protein synthesis.
Azelaic acid acts as antibacterial by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes.
In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases.
In anaerobic bacteria, azelaic acid impedes glycolysis.
azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedon formation.
Azelaic acid is effective against both inflamed and noninflamed lesions.
It also reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Azelaic acid is used for topical gel treatment for rosacea.
This is because of its ability to reduce inflammation.
It clears the bumps and swelling that are due to rosacea.
azelaic acid is used for lightening skin pigmentation including post inflammatory hyperpigmentation and melisma. Azelaic acid is a tyrosinase inhibitor, and it has the ability to stop the synthesis of melanin
It acts as anti-inflammatory, anti-microbial, antioxidant, anticomedolytic, antiacne , antiproliferative agent, antifungal it binds to membrane sterols, lacquers, plasticizers, adhesive, polyamides, urethane elastomers and organic synthesis.
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