• What is collagen?
• What collagen does to the body?
• Collagen Prevents and treats osteoporosis and osteoarthritis
• Collagen shows Anti-inflammatory effect and antitumor effect
• Intake of collagen Reduces the risk of cardiovascular diseases
• Collagen helps metabolism in the body
Collagen consist of structural protein with different connective tissues, such as skin, bone, cartilage and tendons, and comprises about one-third of total proteins in humans. It is extracted from collagen materials with hot water it is known as gelatin. The further enzymatic hydrolysis of gelatin results in collagen. Collagen is a fibrous protein present in the extracellular matrix and connective tissue of animals. Collagen consist of 25-30% of the protein content in the whole body especially in mammals. Collagen is formed by the fibroblast of connective tissue and also by different type of other epithelial cells.
Collagen shows good antioxidant activity. Intake of collagen also increases the activities of antioxidant enzymes in body, including superoxide dismutase, Glutathione peroxidase. Intake of collagen increases skin hydration, decreases the formation of deep wrinkles and improves skin elasticity.
collagen promotes an improves the symptoms of osteoarthritis and osteoporosis. combined intake of collagen with calcium and vitamin D has better effects. And it enhances wound healing.
Glycine is present in collagen and it is a major structural unit, one third of the amino acid is present in it. Collagen has the ability to reduce inflammatory responses. It inhibits the production of pro-inflammatory cytokine via glycine-gated chloride channels (GlyR). Collagen intake inhibits the tumor incidence and increases the life span. It inhibits the platelet release and down regulated proangiogenic factors in blood. As angiogenesis is the key importance for the process of tumor progression.
Collagen shows antihypertensive effect. Oral administration of collagen decreases systolic blood pressure by inhibiting angiotensin I converting enzyme (ACE) and intake of collagen tripeptide had an inhibitory effect on atherosclerosis. Platelets are involved in the pathophysiology of atherosclerosis and thrombosis. collagen has an inhibitory activity on platelet release and platelet aggregation, which may prevent or treat atherosclerosis and thrombosis-related cardiovascular diseases.
Collagen intake shows effect on the absorption and metabolism of lipid and glucose. collagen reduces high fat diet-induced body weight gain and regulates serum levels of total cholesterol, triglyceride and low-density lipoprotein. intake of collagen could alter lipid metabolism-related gene expression. It shows hypoglycemic effects. Collagen improves glucose tolerance by inhibiting intestinal glucose uptake and enhancing insulin secretion, and shows antidiabetic property.
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